If your Personas service and your RestGUI services have a different host or port then connecting to the system in Chrome can cause problems.
Problem: Connecting to a system in a different domain using basic authentication does not work because the username/password popup does not appear.
Solution: According to Google this behavior is intentional because it is a phishing defense mechanism (http://code.google.com/p/chromium/issues/detail?id=91814). To enable accessing systems in a different domain/port with basic authentication, launch chrome with the --allow-cross-origin-auth-prompt flag. After starting Chrome with the above mentioned flag is works fine.
Cheers,
Tobias.